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Intraperitoneal Delivery of Adaptive Natural Killer (NK) Cells (FATE-NK100) With Intraperitoneal Interleukin-2

Intraperitoneal Delivery of Adaptive Natural Killer (NK) Cells (FATE-NK100) With Intraperitoneal Interleukin-2 in Women With Recurrent Ovarian, Fallopian Tube, and Primary Peritoneal Cancer

Phase 1

Doctors at the Masonic Cancer Center of the University of Minnesota seek female patients with intraperitoneal primary tumors or recurrent ovarian or fallopian tube cancer that meets clinical criteria for its recurrence. These patients may be eligible for an investigatory treatment of donated (allogeneic) natural killer (NK) immune cells that target and may help to control tumors, along with in cell messengers (interleukin-2, or IL-2) to promote the immune system to fight the tumors. The trial seeks to determine best doses of NK cells.

Treatment will involve a cycle of chemotherapy, then the infusion of donor-matched NK cells and IL-2. Follow up continues for at least 1 year.


  • Be female, 18 years to 75 years old
  • Have a diagnosis of one of the eligible types of tumors
  • Able to be off prednisone or other immunosuppressive medications for at least 3 days prior to FATE-NK100 cell infusion


  1. Screening to confirm acceptance to the study.
  2. Participants assigned to a dose level of NK cells based on when study is joined.
  3. Participants receive chemotherapy (Cyclophosphamide and Fludarabine), then receive NK cells intravenously.
  4. Interleukin-2 is given with the NK cells, three times a week for a total of 6 doses. The 1st dose will be given immediately (within 30 minutes) after the FATE-NK100 cell infusion as an inpatient. The remaining doses will be given in an outpatient setting.
  5. Follow up will continue for at least 1 year after discharge.


The study will take place at the Masonic Cancer Center, University of Minnesota. Map.

Contact: Kimberly Brunsvold  |  612-626-2315  |  [email protected]




Masonic Cancer Center, University of Minnesota


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