Top
Lung Cancer - Healing Genes
619
post-template-default,single,single-post,postid-619,single-format-standard,mkdf-bmi-calculator-1.0,mkd-core-1.1.1,tribe-no-js,wellspring-ver-1.8,mkdf-smooth-page-transitions,mkdf-ajax,mkdf-grid-1300,mkdf-blog-installed,mkdf-header-standard,mkdf-no-behavior,mkdf-default-mobile-header,mkdf-sticky-up-mobile-header,mkdf-dropdown-slide-from-bottom,mkdf-full-width-wide-menu,mkdf-search-dropdown,elementor-default,elementor-template-full-width,elementor-kit-3486,elementor-page-2540

Lung Cancer

Share This Post

Share on facebook
Share on linkedin
Share on twitter
Share on email

Intratumoral Gene Mediated Cytotoxic Immunotherapy in Patients With Resectable Non-Small Cell Lung Cancer


Phase 1

DESCRIPTION:

University of Pennsylvania researchers seek participants in a clinical investigation of a genetic therapy in combination with standard surgery for non-small cell lung cancer. The investigational therapy is a genetically engineered adenovirus to infect tumor cells and transfer to their DNA a specific gene. When the tumor cells express the gene, they will become sensitive to a prodrug called valacyclovir, which will kill the tumor cells. This tumor cell death may also stimulate the body’s immune cells to attack the tumor. Researchers hope these genes, transferred by the virus, will lead patients’ immune systems to slow or reverse the growth of their tumors.

The steps involve an injection of the virus to the tumor, followed by 14 days of the prodrug, with surgery following another week later. Chemotherapy and/or radiation can be scheduled 6 to 8 weeks after surgery.


PATIENT MUST:

  • Be 18 years of age or older
  • Pathologically documented non-small cell carcinoma
  • The tumor must be 4cm or greater in diameter based on imaging
  • Not be pregnant or breastfeeding
  • Known sensitivity or allergic reactions to valacyclovir

THE STUDY INVOLVES:

  1. Prescreening tests to confirm eligibility of the patient to participate.
  2. Injection of the investigational drug directly to the tumor
  3. 14 days of valacyclovir prodrug, administered orally
  4. Surgical resection of the tumor ~ 3 weeks after step (2)
  5. Chemotherapy or radiation, as directed by the oncologist, may begin 6 to 8 weeks after surgery
  6. Follow up will continue at 6 weeks, 12 months, and 5 years.

LOCATIONS AND CONTACTS:

The study site is at the University of Pennsylvania. Map.

Contacts: Brenda Horn | [email protected] | 215-590-4202

SPONSOR INFORMATION:

Advantagene, Inc.

University of Pennsylvania

Or go online:

https://clinicaltrials.gov/ct2/show/NCT03131037

Subscribe To Our Newsletter

Get updates and learn from the best

More To Explore

Vanquishing the Virus: 160+ COVID-19 Drug and Vaccine Candidates in Development

While President Trump continues to promote antimalarial drugs such as hydroxychloroquine sulfate and azithromycin to treat COVID-19—“What do you have to lose?” he exclaimed during the April 4 Coronavirus Task Force Briefing—the global community of drug discovery researchers and biopharmas is developing a much broader