Coronary Microvascular Dysfunction - Healing Genes

Coronary Microvascular Dysfunction

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Safety and Potential Bioactivity of CLBS14 in Patients With Coronary Microvascular Dysfunction and Without Obstructive Coronary Artery Disease

An Open-Label Exploratory Clinical Study to Evaluate the Safety and Potential Bioactivity of CLBS14 in Patients With Coronary Microvascular Dysfunction (CMD) and Without Obstructive Coronary Artery Disease

Phase 2


Doctors at Cedars-Sinai Medical Center in CA and the Mayo Clinic in MN seek patients with coronary microvascular dysfunction and without obstructive coronary artery disease. The treatment selects particular immune T-cells that are have innate ability to repair small blood vessels for microcirculation, multiplies them outside the body, then re-administers them to the patient. In addition, an immune-stimulating medicine (GCSF) will be administered prior to the collection of stem cells to increase their numbers.

After GCSF medication, study participants will undergo a blood draw treatment that sorts out specific stem cells and returns the blood to the patient. After the cells are multiplied and re-infused, follow-up will last at least a year.


  • Be 18 years of age or older
  • Have no obstructive coronary artery disease
  • Not be pregnant or lactating


  1. Screening before the treatment
  2. Following GCSF medication, leukapheresis will draw the needed immune cells but return blood cells to the body.
  3. The gene-modified immune cells will be re-infused to the patient.
  4. The patient will be closely assessed during treatment, with follow-up for 1 year.


Trials will take place at the Cedars-Sinai Medical Center in Los Angeles, CA, Map, and

Mayo Clinic in Rochester in Rochester, MN, Map.


Chrissy Kotynski  |  (908) 842-0093  |  [email protected]

Scott Volk  |  (949) 346-8784  |  [email protected]


Caladrius Biosciences, Inc.

National Heart, Lung, and Blood Institute (NHLBI)

Cedars-Sinai Medical Center

Mayo Clinic

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