Asthma - Healing Genes


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Trial of Mepolizumab Adjunctive Therapy for the Prevention of Asthma Exacerbations in Urban Children (MUPPITS-2)

Mechanisms Underlying Asthma Exacerbations Prevented and Persistent With Immune-Based Therapy: A Systems Approach Phase 2 (ICAC-30)

Phase 2


Doctors at several US medical facilities are conducting a large-scale study to learn if an already FDA-approved medication, called Nucala® (mepolizumab), given along with standard asthma care, makes children less likely to have asthma attacks. While approved for older children, the age range being studied is 6 to 17 years of age. The drug is an antibody that  study will require an injection under the skin every 4 weeks for 56 weeks, and a portion of the participants will receive a placebo injection.

Nucala works by blocking an immune system reaction by eosinophils that contributes to asthma attacks. Learn more about Nucala here.


  • Be 6 to 17 years of age
  • Lives within appropriate distance from the study center
  • Have a diagnosis of arthritis longer than 1 year prior to enrolling in the study
  • Participant has had ≥2 asthma exacerbations in the prior year
  • Has had varicella or varicella vaccination (chicken pox)
  • Meet criteria regarding the status of their asthma progression and severity


  1. Prescreening tests to confirm eligibility of the patient to participate.
  2. Visits to the study center every 4 weeks for injection and observation
  3. In-depth follow up at regular 12-week intervals to assess whether the drug is reducing asthma symptoms and severity, for ~ 1 year


Several locations are involved in this large study:

Children’s Hospital Colorado in Aurora, Colorado

Contact: Pascuala Pinedo-Estrada  |  720-777-8077 | [email protected]


Children’s National Medical Center in Washington, District of Columbia

Contact: Alicia Newcomer  |  202-476-4698  |  [email protected]


Ann and Robert Lurie Children’s Hospital of Chicago  in Chicago, Illinois

Contact: Sarah Godley    312-227-6454    [email protected]


Boston University School of Medicine in Boston, Massachusetts

Contact: Lisa Gagalis  |  617-414-3263  |  [email protected]

Contact: Edlira Gjerasi  |  (617) 414-3263  |  [email protected]


Henry Ford Health System in Detroit, Michigan

Contact: Sherae Hereford  |  313-916-6954  |  [email protected]

Contact: Debbie Emmer  |  313 916-6966  |  [email protected]


St. Louis Children’s Hospital in Saint Louis, Missouri

Contact: Beth Tesson  |  314-286-1290  |  [email protected]


Columbia University Medical Center New York, New York

Contact: Marcela Pierce  |  212-305-6255  |  [email protected]


Cincinnati Children’s Hospital  Cincinnati, Ohio

Contact: Kristi Curtsinger  |  513-803-1651  |  [email protected]


University of Texas Southwestern Medical Center Dallas, Texas

Contact: Dolores Santoyo  |  214-648-2620  |  [email protected]



The National Institute of Allergy and Infectious Diseases (NIAID)

Inner-City Asthma Consortium




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